Thus, receptors can initiate signals to both traditional and G protein–independent pathways and can control the relative activity of these cascades according to the chemical nature of the bound ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

But how does this happen? "It is as if G-protein signaling causes the channel to need more 'persuasion'—in terms of stronger electrical signals—to open. In our study, we describe at the ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...