G protein-coupled ... activates heterotrimeric G proteins (guanine nucleotide-binding proteins), which are important for transmitting the extracellular, ligand signal to the cell interior.

Previous studies have shown that IBDV infection antagonizes the type I interferon production to facilitate viral replication in the cell, and IRF7 signaling ... After 12,000×g centrifugation, the ...

Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain ...

Ozempic and Wegovy do the same thing as GLP-1 would normally do for you — but to enable them to treat diabetes and obesity, ...

Increased understanding of signal transduction mechanisms and gene regulation involved in immune responses has created opportunities for the discovery of novel therapeutic compounds useful in treating ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz ...

Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

Cytokines, extracellular matrix molecules, cell-surface molecules, membrane-associated molecules, G-proteins, cytoskeletal molecules and signal transduction proteins are involved in neuronal and ...

A study of rare familial genetic mutations linked to early-onset dementia supports the idea that stalled protein processing contributes to Alzheimer’s disease. Alzheimer’s disease is likely caused by ...

They also realized that the β-adrenergic receptor was one of many in a whole family of receptors that function in the same way. This family is now known as G-protein-coupled receptors, and the studies ...