Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

In obesity and insulin resistance ... mechanism of PKC activation is through ligand binding to G-protein-coupled receptors, which for example occurs during α-adrenergic stimulation.

Insulin receptors are widely expressed and distributed across the brain and are mainly the insulin receptor-A isoform rather ...

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Type 1 Diabetes Cells have the normal number of insulin receptors on their surface. They respond to the presence of insulin Type 2 Diabetes Cells have a decreased number of insulin receptors on ...