In conclusion, hope for more efficient, individualized, and secure therapies may come from continuing research and breakthroughs in novel diabetes treatment targets. These developments are at the ...

In obesity and insulin resistance ... mechanism of PKC activation is through ligand binding to G-protein-coupled receptors, which for example occurs during α-adrenergic stimulation.

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Impaired insulin receptor signaling is ...

Insulin receptors are widely expressed and distributed across the brain and are mainly the insulin receptor-A isoform rather ...

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Type 1 Diabetes Cells have the normal number of insulin receptors on their surface. They respond to the presence of insulin Type 2 Diabetes Cells have a decreased number of insulin receptors on ...

A RECENT population-based analysis has highlighted potential behavioural side effects associated with Glucagon-like peptide 1 ...

A study on GLP1RA medications found that behavioral side effects likely do not result from direct action on GLP1R.

Average price per insulin unit dropped 42%, from $0.33 in 2019 to $0.19 in mid-2024 -- the lowest average recorded in a ...