The protein expression related to PI3K/Akt/Nrf2 pathway was detected by using Western blotting. Finally, co-immunoprecipitation was used to study the molecular interaction between Keap1 and Nrf2.

(b) Are there intermediary proteins that convey the effect to the Nrf2/Keap1 complex or is eugenol directly disrupting ... by which EUG inhibits the NRF2-mediated anti-oxidative stress pathway.

This study aimed to test NPA7’s ability to inhibit oxidative stress by modulating the p62-KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2-related factor 2) pathway in ...

Figure 1. A cell-type–specific positive feedback loop of the signaling pathway in HO-1/CO. Figure 2. Prosurvival signaling by CO is mediated by the induction of HO-1 via PERK-Nrf2–dependent pathway.

In human studies, Nrf2 suppression has been linked to cataract formation in lenses collected from diabetic and older patients, with the upregulation of Keap1 (an Nrf2 suppressor) found in these ...

The present study suggested that EUG exerted protective effects on pancreatic β cells in T1DM by attenuating apoptosis and oxidative stress through the activation of the NRF2 signaling pathway.