Aniridia is caused by mutations in the PAX6 gene. This gene plays an important role in forming tissues and organs during an embryo's development. Your baby's eye color is determined by genetics. Eye ...

Currently, drug targets are largely validated using in vitro assays and animal models which may not translate well to human disease. Emerging methods from human genetics, such as Mendelian ...

Mendelian randomization offers a novel approach to reveal causality and address ... Individual variability: There is significant variability in immune cell phenotypes and responses among individuals, ...

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Genetics can play a role in having obesity. Twin studies have found the heritability of obesity to be approximately 40% to 75%. Up to 500 obesity-related genes have been recognized in humans. Although ...

However, it cannot be directly applied when many traits need to be considered. In contrast, Mendelian randomisation Bayesian model averaging (MR-BMA), a Bayesian approach first described by Zuber et ...

We then applied rhapsodi to the sperm sequencing data to investigate adherence to Mendel’s Law of Segregation, which states that the offspring of a diploid, heterozygous parent will inherit either ...

Our aim was to assess the causal link between plasma Hcy level and cerebrovascular and neurodegenerative diseases through a Mendelian randomization (MR) study. Methods: A two-sample MR study was ...

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Although Mendelian randomization techniques can involve fairly computationally intensive analyses, the fundamental principles that guide these study designs are straightforward and if understood ...