Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...

Chlorcyclizine shows promise in reducing protoporphyrin-IX accumulation and liver damage in erythropoietic protoporphyria, ...

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and incubated with suitable secondary antibodies (Goat anti-Mouse IgG HRP or Goat anti-Rabbit IgG HRP) at room temperature for 1 h. A chemiluminescent reagent (Beyotime, China) and a ChemiDoc MP ...

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as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...

To check the role of TRIM32 in INSR signaling, we overexpressed TRIM32 in mouse primary hepatocytes. We found that ectopic expression of TRIM32 was sufficient to blunt pINSR(Y1150), with consequent ...

To investigate the potential contribution of hepatocyte cellular senescence to the metabolic derangements associated with non-alcoholic steatohepatitis (NASH), we treated human hepatocyte cell lines ...

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