have been difficult to replicate in organoids. The present study aimed to develop an ex vivo model that could mimic the ...

Cancer remains one of the most complex diseases, with its diverse molecular profiles and cellular compositions posing ...

Interestingly, these processes are all sensitive to the concentration of oxygen present in the microenvironment. Rapidly proliferating cells cause the NSCLC tumor to extend beyond the oxygen ...

While comparing mechanical dissociation and enzymatic digestion for generating patient-derived organoids (PDOs), they emphasize the importance of maintaining the tumor microenvironment ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

they built a large-scale library of tongue cancer organoids (TCOs) from surgery samples of 28 patients. Organoids are three-dimensional tissue models that mimic organs. As explained in their paper ...

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit. Our ...

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids ...

While these organoids are derived from cancer cell lines and don’t accurately recapitulate the complexity of the tumor microenvironment, the team plans to test their approach using patient-derived ...

A team from the German Cancer Research Center (DKFZ), the Heidelberg Stem Cell Institute HI-STEM and the NCT Heidelberg has now succeeded for the first time in cultivating stable tumor organoids ...