To investigate whether the Cdc2-like kinase 2 (CLK2) is expressed in hypothalamic neurons and if it is, whether the hypothalamic CLK2 has a role in the regulation of energy balance. Thus ...

A high-resolution spatial map of the human hypothalamus makes it possible to identify specific cells, determine their exact location and analyze their neighboring cells. The cell atlas ...

The hypothalamus is a central region of the brain that controls vital functions such as sleep, body temperature, hunger and thirst. Because the human brain is difficult to study, much knowledge about ...

me.com Objectives To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols. Methods Brain cMRI (1.5 Tesla) scans of 105 ...

Hcrtr1 mRNA is prominent in the prefrontal and intralimbic cortex, hippocampus, paraventricular thalamic nucleus, ventromedial hypothalamic nucleus, dorsal raphe nucleus and locus coeruleus.

This important work explores the modulation of pain by intense stress. The authors employed a series of cutting-edge techniques and provided convincing evidence suggesting that the dorsal lateral ...

Background: The ventromedial hypothalamus (VMH) is an important nuclei in responding to emotional stress, and emotional stress is a risk factor for cardiovascular diseases. However, the role of the ...

More recently, studies using precise circuit manipulation tools have identified a small subnucleus in the medial hypothalamus, the ventrolateral part of the ventromedial hypothalamus (VMHvl), as a key ...

We found that specific subsets of STN neurons have activity consistent with causal roles in reactive action stopping or switching. Importantly, these neurons were strictly segregated to a ventromedial ...

One site where GABA has a tonic influence on arterial blood pressure (ABP), heart rate (HR), and sympathetic nerve activity (SNA) is the hypothalamic paraventricular nucleus (PVN). Indeed, studies ...