A third autotrophic pathway (Wood–Ljungdahl pathway) uses a reductive acetyl-CoA pathway and is only found in strictly anaerobic bacteria and archaea. A fourth pathway uses the 3 ...

Scientists from the Lebanese American University investigated the role of acetyl-CoA synthetase short chain family member 2 (ACSS2) in inflammatory bowel disease, including ulcerative colitis and ...

Through producing acetyl-CoA from acetate, ACSS2 epigenetically controls gene expression. However, whether and how ACSS2 regulates senescence remains unclear. Here, the authors link ACSS2 ...

Metabolome analyses showed that PanK4 plays a role in the regulation of acetyl-CoA in the skeletal muscles. The absence of PanK4 led to a significant increase in acetyl-CoA, which impaired the ...

A previous review has supported the critical role of acylcarnitine in fatty acid metabolism, ketosis and buffering the concentration ratio of acyl-CoA to free CoA in brain metabolism in neurological ...

This was highlighted in one of more recent publications, (1) where a multiomics approach was used to investigate the implications of the metabolic enzyme ACSS2, which is required in the synthesis of ...

Two forms of Kla have been described, including K (L-la) and K (D-la). The K (L-la) proposed by Zhang et al. described an enzymatic mechanism, where l-lactate was first transformed into its activated ...

Hepatocellular carcinoma Fatty acid synthase Cholesterol biosynthesis HMG-CoA reductase Systems biology This is an open access article distributed in accordance with the Creative Commons Attribution ...