【导读】利用核糖核酸酶靶向嵌合体（RiboTACs）降解RNA，是一种很有前景的癌症治疗方法。然而，潜在的脱靶降解是一个严重的问题。在这项研究中，团队设计了一种能触发肿瘤微环境激活的RiboTAC。2025年2月3日，苏州大学的研究团队在期刊《Nat ...

Discover the importance of vision, genetic eye disorders, and RNA-based therapies for precision treatment in India and ...

Disinfectants induce oxidative damage in bacteria, but a single mutation triggers the expression of genes that help the ...

Riboswitches are RNA sensors that allow bacteria to sense and respond to their environment. Here, Bushhouse et al. demonstrate that the sensitivity of several riboswitches can be tuned by ...

This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...

Cytosolic isoleucyl-tRNA synthetase (IARS1) deficiency, an exceptionally rare autosomal recessive inherited disorder, is characterized by multiple system involvement, including growth retardation, ...

Biosynthesis can be exploited for chemical synthesis in vitro or in cells like Escherichia coli by combining substrates with enzymes using recombinant methods. The introduction of fluoroalkyl ...