Immunogenicity assessment is a critical aspect of the development of biotherapeutics, which are drugs derived from biological sources, such as proteins or antibodies. This assessment involves ...

The purpose of this analysis was to examine the immunogenicity of panitumumab and to evaluate the effect of anti-panitumumab antibodies on pharmacokinetic and safety profiles in patients with mCRC ...

Product-related and patient-related factors affecting the immunogenicity of biopharmaceuticals are outlined. ADA: Anti-drug antibody; APC: Antigen-presenting cell; BCR: B-cell receptor ...

Prevalence data on the immunogenicity of biologicals, and of adalimumab in particular, are highly variable. We investigated the prevalence of anti-adalimumab antibodies and the association with ...

This whitepaper explores how innovative chromatography solutions can improve aggregate removal while maintaining high product ...

However, a notable challenge in the management of RA is the immunogenicity of these biologic therapies, which can lead to the formation of anti-drug antibodies (ADAb). These antibodies can reduce ...

Valneva (VALN) announced results for its Phase 2 clinical trial evaluating the safety and immunogenicity of two different ...

In cases of treatment failure, it is important to understand why treatment has failed as this can guide future biologic choices. The formation of anti-drug antibodies (ADA) can occur with all ...

(B) Immunogenicity of vaccine candidates in hamsters. Neutralizing antibody titers in the sera were measured 21 days post-inoculation. Supplementary fig. 2 Persistence of the neutralizing antibodies ...

In this interview, Technology Networks spoke with Dr. Sophie Mayle, Dr. Paul Royle and Dr. John Cardone from Bio-Rad's ...