These findings in the human are at the basis of our proposed structure-function model in which the antigen binding features of the germline template antibody are dictated by the somatically ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

A diagram showing the impact of secretory IgA antibody binding on commensal bacteria. Healthy subjects (right) bind to a balanced variety of bacterial species with IgA and IgM, while IgA-deficient ...

Antibodies usually have a Y-shaped structure, and these hypervariable regions are located in the tips of the Y, where they detect and bind to foreign proteins, also known as antigens. The bottom ...

A research team led by a Duke professor recently developed a novel computational model to predict antibody structures, a significant breakthrough for disease prevention efforts. A study published ...