Introduction: Mutations of hepatitis B virus (HBV) polymerase ... plus L180M were detected without the presence of wild YMDD motif. Conclusion: Naturally occurring YMDD motif variants were ...

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The C2C2Bw4+ environment, marked by strong -21T motifs, favors the expansion of the NK cell population expressing only ... Categorical data were analyzed using the chi-square test, and univariate ...

During the past few years one of the most astonishing findings in the field of virology has been the realization that viruses that infect hosts from all three domains of life are often ...

Briefly, the full-length, deletion fragments and different domains of NLRP12 were amplified and inserted into a multi-cloning site of the PSG5 vector. The mutation of NLRP12 walker A/B motif were ...

Assembly of bacterial ring-shaped hexameric replicative helicases on single-stranded (ss) DNA requires specialized loading factors. However, mechanisms implemented by ...

In all analyzed structures of diverse P-loop NTPases, the conserved P-loop motif keeps the triphosphate chain of bound NTPs (or their analogs) in an extended, catalytically prone conformation, similar ...