The faithful replication and segregation of the DNA is dependent on the existence of checkpoints that monitor the accuracy of these events and prevent cell-cycle progression when problems arise.

To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant, Psoralea corylifolia, that synergistically ...

Nagayama, K. and Hirooka, Y. (2025) Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance. Journal of Biosciences and Medicines, 13, 230-242.

IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and IBC enhances DNA damage to a level that triggers cancer cell death. IBC and BKC extend survival and induce replication ...

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.

EBNALP alters looping factor YY1 DNA binding and 3D genome organization which might facilitate cell cycle progression and prevent cell death. EBNALP is tethered to DNA by DPF2. EBNALP recruits YY1 to ...

Alcohol consumption can elevate cancer risk through mechanisms such as DNA damage, hormonal changes, and oxidative stress, with risks increasing alongside consumption levels.

The expanding oncology pipeline in the USA is a key driver for cytotoxic drug demand, with over 1,000 oncology drugs in development. Advancements in ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Throughout the cell cycle, magnesium is essential for stabilizing ... Thus, magnesium plays a crucial role in the DNA replication process and preservation of genome stability.

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.