The expanding oncology pipeline in the USA is a key driver for cytotoxic drug demand, with over 1,000 oncology drugs in development. Advancements in ...

Nagayama, K. and Hirooka, Y. (2025) Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance. Journal of Biosciences and Medicines, 13, 230-242.

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.

After an allogeneic stem cell transplant, a recipient’s body faces a daunting task: rebuilding the person’s blood-forming and immune systems from the ground up from a relatively small number of “seed” ...

Finally, the WEE1 kinase has been shown to stop cell-cycle progression following an arrest of DNA replication and DNA-damage stress. For the coming years, it will be a challenge to find out how ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Ancient DNA unlocks new understanding of migrations in the first millennium AD. ScienceDaily . Retrieved January 21, 2025 from www.sciencedaily.com / releases / 2025 / 01 / 250101132012.htm ...

IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and IBC enhances DNA damage to a level that triggers cancer cell death. IBC and BKC extend survival and induce replication ...

When you get that back, it's incredible. Literally incredible." Every cell in the body contains each person's distinctive DNA, as well as mitochondria, which provides the cell its energy.

We found coordinate upregulation of transcripts involved in cell-cycle control, DNA replication and chromosome segregation, providing a basic validation of the approach (Figs. 2 and 3).

Zinc finger E-box binding homeobox 1 (ZEB1) is a prime element of a network of transcription factors controlling EMT and has been identified as an important molecule in the regulation of DNA damage, ...