These basic processes, known collectively as the cell cycle ... This process involves replication of the cell's chromosomes, segregation of the copied DNA, and splitting of the parent cell's ...

When the fork stalls due to an obstacle on the DNA (Figure 1), the cell activates the replication checkpoint to send a signal to arrest the progression of the cell cycle. Another example of ...

A team has unearthed new findings about what happens during the minutes and hours after a cell divides, expanding our understanding of human biology -- and potentially leading to better medicines.

We also discovered that this breakage mechanism only occurs at the beginning of the cell cycle phase, when DNA replication ...

The precision of this process depends in large measure upon stringent regulatory mechanisms that couple DNA replication to cell cycle progression. Initiation must be triggered at the appropriate time ...

Replication of DNA DNA replication is the process by which a cell makes an identical copy of its DNA. Gene expression Only a fraction of the genes possessed by any particular cell will be expressed.

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

Harvest cells, want good single cell suspension Count cells Dispense aliquots of 1 million cells into labeled tubes Add 5 ml PBS and centrifuge for 5 min at 400 x g. Re-suspend cell pellet in 300 ul ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Nagayama, K. and Hirooka, Y. (2025) Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance. Journal of Biosciences and Medicines, 13, 230-242.

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.