New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ ...

We show here that extracellular matrix proteins interact with soluble CD95L and potentiate its pro-apoptotic activity. The cytotoxicity of supernatants from CD95L-expressing cells was increased by ...

A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy ...

The orderly arrangement of cells in tissues depends on complex signaling between cells. Learn how cellular junctions play important roles in cell adhesion and communication.

New research published in Nature Communications reveals how cancer cells are altered by their surroundings, enabling them to ...

So far, Fiore's new direction is paying off. The extracellular matrix supports and gives structure to our cells and tissues: It provides a scaffold for cells to grow in, dictates the mechanical ...