Aniridia is caused by mutations in the PAX6 gene. This gene plays an important role in forming tissues and organs during an embryo's development. Your baby's eye color is determined by genetics. Eye ...

Currently, drug targets are largely validated using in vitro assays and animal models which may not translate well to human disease. Emerging methods from human genetics, such as Mendelian ...

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This article aims to provide an overview of three genetic epidemiology methods for polygenic (or complex) diseases: genome-wide association studies (GWAS), Polygenic Risk Scores (PRS) and Mendelian ...

Mendelian randomization offers a novel approach to reveal causality and address ... Individual variability: There is significant variability in immune cell phenotypes and responses among individuals, ...

Genetics can play a role in having obesity. Twin studies have found the heritability of obesity to be approximately 40% to 75%. Up to 500 obesity-related genes have been recognized in humans. Although ...

Our aim was to assess the causal link between plasma Hcy level and cerebrovascular and neurodegenerative diseases through a Mendelian randomization (MR) study. Methods: A two-sample MR study was ...

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Although Mendelian randomization techniques can involve fairly computationally intensive analyses, the fundamental principles that guide these study designs are straightforward and if understood ...