Here, as a solution to this problem, we report the generation of human fibroblast-derived hepatocytes that can repopulate mouse livers. Unlike current protocols for deriving hepatocytes from human ...

Biao Fan, Yann Malato, Diego F Calvisi, Syed Naqvi, Nataliya Razumilava, Silvia Ribback, Gregory J Gores, Frank Dombrowski, Matthias Evert, Xin Chen, Holger Willenbring This study shows that mouse ...

So far, Ochiya and his team have shown that mouse and rat hepatocytes extracted from livers, even damaged ones, can be reprogrammed into proliferative cells in vitro using a combination of low ...

Hepatocytes has elevated autophagy level and have been used to study various types of autophagy including micro autophagy, chaperone-mediated autophagy (CMA) and selective autophagy. We have ...

This study aimed to develop an HBV-induced chronic hepatitis and cirrhosis mouse model through transplantation of human bone marrow mesenchymal stem cells (hBMSCs). Results The implantation of hBMSCs ...

Seven days after the injection, the mice were treated with vehicle or Tm (2 mg/kg, i.p.) and were killed 72 h afterwards. HepG2 (human hepatocyte-derived cell line) and AML12 (mouse hepatocyte-derived ...