鸢尾素是一种内源性肌细胞因子，具有抗炎和抗氧化特性，且能穿越血脑屏障在大脑中发挥神经保护作用。然而，其在朊病毒病中对抗氧化应激和线粒体功能障碍的具体作用机制尚不明确。本研究旨在评估鸢尾素在朊病毒病模型中的保护作用，并深入探究其潜在机制。

This study aimed to test NPA7’s ability to inhibit oxidative stress by modulating the p62-KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2-related factor 2) pathway in ...

This useful study partially succeeds in providing solid evidence in support of the therapeutic potential of the plant-derived compound eugenol for ameliorating symptoms associated with STZ-induced ...

As a crucial regulator of redox balance, nuclear factor erythroid 2-related factor 2 (Nrf2) governs the transcription of downstream antioxidant enzymes (Huang et al., 2022; Shen et al., 2019). Under ...

Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

In this manuscript, the authors consider the effects of eugenol (EUG), a plant-produced substance known to reduce oxidative stress in various cellular contexts via Nrf2, in alleviating the effects of ...

The NYPD on Sunday released surveillance footage of the sicko who tried to rape a 32-year-old woman in Queens early Friday before a good Samaritan chased the creep away.

Background—Reactive oxygen species contribute to tissue injury in inflammatory bowel disease (IBD). The tripeptide glutathione (GSH) is the most important intracellular antioxidant. Aims—To ...