编者按代谢功能障碍相关脂肪性肝病（MASLD）及代谢功能障碍相关脂肪性肝炎（MASH）是全球范围内日趋严重的健康问题。肝脏作为人体的代谢中心，通过整合来自胃肠道和脂肪组织的信号，调节碳水化合物、脂质和氨基酸的代谢。然而，肥胖、胰岛素抵抗和2型糖尿病等 ...

Through producing acetyl-CoA from acetate, ACSS2 epigenetically controls gene expression. However, whether and how ACSS2 regulates senescence remains unclear. Here, the authors link ACSS2 ...

A previous review has supported the critical role of acylcarnitine in fatty acid metabolism, ketosis and buffering the concentration ratio of acyl-CoA to free CoA in brain metabolism in neurological ...

Hepatocellular carcinoma Fatty acid synthase Cholesterol biosynthesis HMG-CoA reductase Systems biology This is an open access article distributed in accordance with the Creative Commons Attribution ...

Fifteen lean (BMI: 22.1 ± 0.5 kg/m2) and fourteen obese (40.6 ± 1.4 kg/m2) men and women were recruited to undergo an oral glucose tolerance test (OGTT) and skeletal muscle biopsies. Characteristics ...