This study reveals that PRMT1 overexpression drives tumorigenesis of acute megakaryocytic leukemia (AMKL) and that targeting PRMT1 is a viable approach for treating AMKL. While the evidence, based ...

Pathway 5 (steps 1–2–3 in Figure 4a) is a hybrid pathway, which includes a chemical step converting acetate to acetoacetate. Examining the patent literature suggested this step was likely misannotated ...

COA’s 2023 audit report released on December 1, 2024, said that from 2014 to 2023 the AFP paid out P615.64 million to 7,210 deceased pensioners. In the 2023 report of the General Headquarters ...

acetyl-CoA. In microbes and mammals ACS activity is regulated by the post-translational acetylation of a key lysine residue. ACS in plant cells is part of a two-enzyme system that maintains acetate ...

Here, we examined the effect of different carbon sources that are involved in the major metabolic pathways of acetyl-CoA synthesis on myocardial infarction and found that elevation of acetyl-CoA by ...

Metabolic control of histone acetylation is predominantly achieved through the acetyl group donor acetyl-CoA (14). In addition, histone deacetylation by a family of sirtuin histone deacetylases is ...