Provides consensus recommendations for screening low risk and high risk patients for chloroquine and hydroxychloroquine toxicity. Published in Ophthalmology, March 2016, Vol. 123, 1386-1394.

Hydroxychloroquine (Plaquenil) and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina . Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease

2011年6月1日 · On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful.

2019年9月1日 · Several systemic drugs, including hydroxychloroquine, ethambutol, pen­tosan, thioridazine, and various cancer drugs, are known to cause toxicity to the posterior segment of the eye. Keep­ing them in mind can help preserve a patient’s vision.

We demonstrate how sequential plots of macular thickness using standard OCT measurements can often identify a discrete onset of rapid retinal thinning and thus enable objective recognition of hydroxychloroquine toxicity changes years earlier than present techniques.

Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20% after 20 years of treatment. This review aims to provide an update on HCQ/CQ retinopathy.

Retinal toxicity is a very rare side effect of the hydroxychloroquine therapy, but when it has occurred, vision loss may be permanent and may progress even years after the cessation of medication. Patients would be examined every 3 months, then annually, until they are stabled.

2017年3月10日 · Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost...

2023年4月25日 · Hydroxychloroquine (HCQ) confers survival benefit among patients with autoimmune disease, but with an increased risk of vision-threatening retinopathy if dosed above 5 mg/kg/day.1 Despite updated guidelines from the American Academy of Ophthalmology and American College of Rheumatology in 20162 recommending dosing below that threshold, up …

Despite controversial risks and benefits of HCQ treatment on COVID-19, HCQ is well known to doctors for their side effects in long term usage, especially the ocular toxicity.