Identification of Clec7a as the therapeutic target of rTMS in ...
2023年12月1日 · Clec7a was identified to be the potential target for PD of rTMS administration. Clec7a knockdown rescued motor deficiencies of PD rats. Clec7a knockdown restored …
mTOR-dependent translation amplifies microglia priming in …
2020年10月27日 · In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus critically …
Blocking Dectin-1 prevents colorectal tumorigenesis by …
2023年3月17日 · Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is …
Activation of the innate immune receptor Dectin-1 upon ... - Nature
2011年4月27日 · Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects β-glucans …
Cell：聚焦小胶质细胞中SYK依赖和非依赖途径在阿尔茨海默病中的 …
2022年11月20日 · 作者证实，对携带功能低下的TREM2R47H变体的5xFAD小鼠系统性给予激动性抗CLEC7A抗体，可促进SYK信号传导并改善小胶质细胞激活。 最后，作者挖掘了人类AD …
An inducible genetic tool to track and manipulate specific …
2024年5月30日 · Here, we generated an inducible Cre driver line, Clec7a-CreER T2, that targets PAMs and DAMs in the brain parenchyma. Utilizing this tool, we profiled labeled cells during …
Identification of Clec7a as the therapeutic target of rTMS in ...
Clec7a is a pattern recognition receptor involved in neuroinflammation. The higher expression of Clec7a was observed in the substantia nigra (SN) and striatum of PD rats with dopaminergic …
Cell：聚焦小胶质细胞中SYK依赖和非依赖途径在阿尔茨海默的作用 …
近日，来自美国华盛顿大学医学院病理学和免疫学系的 Marco Colonna 教授团队在 Cell 杂志在线发表了题为 “lTREM2 drives microglia response to amyloid-β via SYK-dependent and …
CLEC7A蛋白：免疫调节与宿主防御的关键角色 - ChemicalBook
2024年9月29日 · 在复杂的生物免疫系统中，C型凝集素域家族7成员A（CLEC7A）蛋白作为一种重要的跨膜受体，广泛表达于单核细胞、树状细胞和骨髓来源的肿瘤细胞中，扮演着至关重要 …
Cell：小胶质细胞导致阿尔茨海默Aβ沉积加剧、认知缺陷的新机制
研究人员采用转基因小鼠策略，构建了小胶SKY条件性敲除的AD模型小鼠5xFADSykΔDMG（Sykfl/flCx3cr1ERT2Cre 5×FADmice. 近来的研究揭示了小胶质细胞及其受 …