Bismuth salts, including ranitidine bismuth citrate, colloidal bismuth subcitrate, and bismuth subnitrate appear to be safe when taken in doses of 400-2100 mg daily for up to 56 days. Bismuth is...

In the 1970s, Gist-Brocades introduced a proprietary preparation of colloidal bismuth subcitrate (De-Nol) as an anti-ulcer therapy by Gist-Brocades in the 1970's. The original De-Nol formulation was a colloidal suspension in ammonia water and had the very pungent odor of ammonia.

Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments.

Colloidal bismuth subcitrate is a complex bismuth salt of citric acid, which forms BiOCl and various structures containing free carboxyl groups and posi- tively charged Bi+ when the bismuth-citrate bonds are opened in the stomach (5,6).

Colloidal bismuth subcitrate (CBS) possesses at least equal efficacy with histamine H2-receptor antagonist drugs in the treatment of peptic ulcer disease. However, CBS has the advantage of slower ulcer relapse rates than those seen after initial healing with the H2-antagonists.

Colloidal bismuth subcitrate (CBS) is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion.

Colloidal bismuth pectin (CBP) is a new, lower-priced bismuth salt made in China. The purpose of this study was to investigate the efficacy and safety of CBP triple and quadruple regimens in the treatment of H. pylori-positive duodenal ulcer.

Colloidal bismuth subcitrate is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion.

2003年9月20日 · Colloidal bismuth subcitrate (CBS, De-Nol) has been used for several decades for the treatment of gastric and duodenal ulcers, and Helicobacter pylori infection together with antibiotics. The solubility of CBS in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3.

Colloidal bismuth subcitrate helps to treat ulcers in the stomach and intestines. It is also used in combination with other medicines for the treatment of Helicobacter pylori infections. Colloidal bismuth subcitrate should be used in the dose and duration as advised by your doctor.