DNA methylation at the promoter of specific genes or gene body methylation affecting splicing can contribute to human diseases. The involvement of DNA modifications in brain development …

2022年2月7日 · DNA/genetic modification is a process that involves base modifications or alterations in the microbial, mammalian, or human genome to achieve targeted goals. It is …

2020年5月22日 · We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third …

2023年9月1日 · Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.

2019年4月23日 · DNAmod is the first database to comprehensively catalogue DNA modifications and provides a single resource to launch an investigation of their properties. DNAmod consists …

The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical …

This book focuses particularly on the newly discovered DNA modifications, enzymatically produced and likely to play specific roles, exploring chromatography- and mass spectrometry …

Deciphering the biological roles of DNA modifications depends on the sensitive detection, accurate quantification, and genome-wide mapping of modifications in genomic DNA. This …

2014年10月22日 · Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins, which establish a complex regulatory network that …

DNA contains a large variety of chemical modifications to the nucleotides. They are increasingly appreciated to mediate important biological functions. Most modifications cannot be accessed …