FTase又称蛋白质脂肪酸转移酵素（或者：法尼基转移酶）。 法尼基转移酶抑制剂（farnesyltransferase inhibitors）是一类正在试验中的分子靶向抗肿瘤药物，其作用的靶分子是细胞信号转导通路中的Ras蛋白。

Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminus of a protein. Farnesyltransferase's targets include members of the Ras superfamily of small GTP-binding proteins critical to cell cycle progression.

法尼基转移酶(FTase)是在蛋白質上加一個15個碳的萜烯而產生了一個CaaX的模段(motif)：一種在蛋白質C端的四個胺基酸序列。 法尼基转移酶的標的蛋白質包括對細胞週期進行很重要的small GTP-bindding protein中Ras superfamily的成員。

法尼基转移酶(FTase)是在蛋白质上加一个15个碳的萜烯而产生了一个CaaX的模段(motif)：一种在蛋白质C端的四个胺基酸序列。 法尼基转移酶的标的蛋白质包括对细胞周期进行很重要的small GTP-bindding protein中Ras superfamily的成员。

法尼基转移酶(farnesyltransferase，FTase) 是一种膜结合蛋白，其可通过对靶蛋白的法尼基化而实现对靶蛋白功能的调控。其中Ras蛋白是FTase最为重要的靶蛋白之一，这是因为大约三分之一的肿瘤存在Ras原癌基因突变。

FTase is a protein prenyltransferase that catalyzes protein farnesylation, which attaches a farnesyl moiety, a 15-carbon isoprenoid to a cysteine residue at or near the C-terminus of protein acceptors, including Ras proteins.

FT又称FTase，英文全称为Farnesyl Transferase，是一类正在试验中的分子靶向抗肿瘤药物，其作用的靶分子是细胞信号转导通路中的Ras蛋白。 Ras蛋白需经翻译后的法尼基化修饰，才能结合于细胞膜并发挥其传导信号的作用。

2001年10月30日 · Protein farnesyltransferase (FTase) catalyzes the attachment of a farnesyl lipid group to the cysteine residue located in the C-terminal tetrapeptide of many essential signal transduction proteins, including members of the Ras superfamily.

2008年11月11日 · Protein farnesyl transferase (FTase) catalyzes transfer of a 15-carbon farnesyl group from farnesyl diphosphate (FPP) to a conserved cysteine in the C-terminal Ca 1 a 2 X motif of a range of proteins, including the oncoprotein H-Ras (“C” refers to the cysteine, “a” to any aliphatic amino acid, and “X” to any amino acid) and the ...

Protein Farnesyltransferase (FTase) is an enzyme that attaches a 15-carbon isoprenoid, called farnesyl, to a specific cysteine residue in proteins, including Ras proteins. This modification, known as protein farnesylation, is crucial for the proper functioning of GTP-binding proteins in the receptor tyrosine kinase signal transduction pathway.