Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is the precursor to all sesquiterpenes, which comprises thousand of compounds. [1] These include all sesquiterpenes as well as sterols and carotenoids. [2]

Farnesyl pyrophosphate (FPPS) synthase (EC 2.5.1.10) is a major chain elongation enzyme of the isoprenoid pathway which belongs to the E-family of the prenyltransferases. Many researchers have used different abbreviations for farnesyl pyrophosphate synthase, like FPS, FDS, FPPS and FDPS; however for the present review we will use FPPS.

Farnesyl pyrophosphate, a metabolic intermediate of the cholesterol synthesis pathway, functions as a novel danger signal to trigger acute cell necrosis, and collaborates with activation of the cation channel TRPM2 to play an important role in brain ischemic injury.

It is a conjugate acid of a 2-trans,6-trans-farnesyl diphosphate (3-). Farnesyl pyrophosphate is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Farnesyl diphosphate has been reported in Tripterygium wilfordii, Myxococcus xanthus, and other organisms with data available. View More...

Endogenous accumulation of farnesyl pyrophosphate (FPP) in epidermal keratinocytes results in global transcriptional changes, affecting major cellular processes: migration, differentiation, inflammation and oxidative stress response.

2021年2月4日 · Classical terpenoid biosynthesis involves the cyclization of the linear prenyl pyrophosphate precursors geranyl-, farnesyl-, or geranylgeranyl pyrophosphate (GPP, FPP, GGPP) and their isomers, to...

2017年1月18日 · Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable...