- LPO is a series of reactions in which polyunsaturated fatty acids are attacked by free radicals that result in the synthesis of lipid peroxides.了解详细信息：LPO is a series of reactions in which polyunsaturated fatty acids are attacked by free radicals that result in the synthesis of lipid peroxides.www.sciencedirect.com/science/article/pii/S098194…
Simplified pathway for lipid autoxidation: Initiated by hydroxyl radical, which abstracts hydrogen and forms a pentadienyl radical (only one resonance structure shown).
en.wikipedia.org/wiki/Lipid_peroxidationIn STING1 pathways, lipid peroxidation can damage mitochondrial and DNA, whereas the release of mtDNA, 8-OHG and damaged DNA activates the STING1-dependent inflammatory pathway via the DNA...
www.nature.com/articles/s41419-024-07244-xLipid signaling may occur via activation of a variety of receptors, including G protein-coupled and nuclear receptors. Members of several different lipid categories have been identified as potent intracellular signal transduction molecules.
pmc.ncbi.nlm.nih.gov/articles/PMC4066722/Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non-apoptotic form of cell death induced by the build-up of toxic lipid peroxides.
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Lipid peroxidation - Wikipedia
Simplified pathway for lipid autoxidation: Initiated by hydroxyl radical, which abstracts hydrogen and forms a pentadienyl radical (only one resonance structure shown). 展开
Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, resulting in the formation of 展开
The chemical reaction of lipid peroxidation consists of three phases: initiation, propagation, and termination.
In the initiation phase, a 展开Antioxidants play a crucial role in mitigating lipid peroxidation by neutralizing free radicals, thereby halting radical chain reactions. Key antioxidants include 展开
Phototherapy may cause lipid peroxidation, leading to the rupture of red blood cell cell membranes.
End-products of lipid peroxidation may be mutagenic and carcinogenic. For instance, the end-product MDA reacts with 展开Certain diagnostic tests are available for the quantification of the end-products of lipid peroxidation, to be specific, malondialdehyde (MDA). The most commonly used test is called a TBARS Assay (thiobarbituric acid reactive substances assay). … 展开
• Lipid+peroxidation at the U.S. National Library of Medicine Medical Subject Headings (MeSH) 展开
CC-BY-SA 许可证中的维基百科文本 Emerging mechanisms of lipid peroxidation in regulated cell death …
2024年11月26日 · In STING1 pathways, lipid peroxidation can damage mitochondrial and DNA, whereas the release of mtDNA, 8-OHG and damaged DNA activates the STING1-dependent …
Lipid Peroxidation: Production, Metabolism, and …
Lipid signaling may occur via activation of a variety of receptors, including G protein-coupled and nuclear receptors. Members of several different lipid categories have been identified as potent intracellular signal transduction …
Targeting Dependency on the GPX4 Lipid Peroxide …
Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non …
Dependency of a therapy-resistant state of cancer cells …
2017年7月5日 · We identify vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts.
Dependency of a therapy-resistant state of cancer cells on a lipid ...
2017年7月27日 · Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid …
癌细胞的抗治疗状态对脂质过氧化物酶途径的依赖性,Nature - X-MOL
2017年7月1日 · 已经提出细胞状态的可塑性会导致对多种癌症疗法的抵抗，从而限制了它们的有效性。在人类肿瘤和癌细胞系中观察到的高间充质细胞状态与对不同癌症谱系的多种治疗方式的 …
Targeting GPX4 in human cancer: Implications of ferroptosis …
2023年4月10日 · Therapy-resistant cancer cells depend more on the GPX4 lipid peroxidase pathway, which is targetable to conferring the vulnerability to ferroptosis [16, 17]. Several …
Lipid Peroxidation: Production, Metabolism, and …
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond (s), especially polyunsaturated fatty acids (...
ROS-induced lipid peroxidation modulates cell death outcome
2023年5月2日 · Lipid peroxidation of phospholipid bilayers can promote mitochondrial apoptosis, endoplasmic reticulum stress, and other complex molecular signaling pathways to regulate …
Lipid Peroxidase Pathway 的相关搜索
