2013年2月24日 · The secretory pathway provides a route for the cell to handle things that might not be good to have in the cytoplasm, and/or are most useful when kept concentrated in a specialized compartment with their desired interacting partners.

At the heart of the cell lies the secretory pathway: an intricate system of organelles that work in concert to produce and modify one-third of all cellular proteins, as well as lipids, which make up the majority of the cell membranes, and carbohydrates, which are attached to most secretory proteins. In plant cells, these organelles also make ...

The secretory pathway is a fundamental cellular process that entails synthesis, modification, sorting and release of secretory proteins to the extracellular milieu or delivery of different components to the cell surface.

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum (ER), which is charged with the tasks of correctly integrating ...

The secretory pathway remains a central paradigm of modern cell biology. Its elucidation 50 years ago inspired tremendous multidisciplinary and on-going efforts to understand the machinery that makes it run, the adaptations that permit it to serve the needs of specialized cell types, and the pathological consequences that arise when it is ...

Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classical mechanism of cell secretion is via secretory portals at the plasma membrane called porosomes. [1] .

2002年1月1日 · This chapter outlines the secretory pathway. The secretory pathway has two main functions. First, it transports newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus and then on to their final destinations. Second, it modifies many of these proteins and lipids during the transport process.

1999年4月1日 · In the secretory pathway, proteins travel from the ER through the Golgi apparatus to arrive at the cell surface or at vacuoles. This biosynthetic, or anterograde, traffic is balanced by retrograde traffic running in the opposite direction.

The paradigm that the secretory pathway consists of a stable endoplasmic reticulum and Golgi apparatus, using discrete transport vesicles to exchange their contents, gained important support from groundbreaking biochemical and genetic studies during the 1980s.

2024年11月15日 · The secretory pathway processes >30% of mammalian proteins, orchestrating their synthesis, modification, trafficking, and quality control.