2021年1月14日 · All eukaryotes—from yeast to humans—express the enzymatic machinery to covalently modify substrate proteins with ubiquitin, a 76 amino-acid residue protein, in a process termed ubiquitination...

Two major proteolytic cascades have been described. Caspases are involved in programmed cell death (apoptosis), whereas the degradation of most short-lived regulatory cellular proteins is mediated by the ubiquitin-proteasome pathway.

Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the proteasome. This article recounts the key observations that led to the discovery of …

2010年12月10日 · The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways are integral to cellular protein homeostasis, and their functional importance in various diseases ...

All eukaryotes—from yeast to humans—express the enzymatic machinery to covalently modify substrate proteins with ubiquitin, a 76 amino-acid residue protein, in a process termed ubiquitination (Fig. 1A).

The ubiquitin proteasome system (UPS) is a proteolytic machinery for the degradation of protein substrates that are post-translationally conjugated with ubiquitin polymers through the enzymatic action of ubiquitin ligases, in a process termed ubiquitylation.

2016年1月25日 · The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. Herein, we will review advances in the understanding of the role of several proteins of the UPS in Alzheimer’s disease (AD) and functional recovery after spinal cord injury (SCI).

2024年10月7日 · The ubiquitin-proteasome system (UPS) is a fundamental component in maintaining protein homeostasis, also known as proteostasis, within cells. Proteostasis encompasses the synthesis, folding, trafficking, and degradation of proteins, ensuring cellular function and health.

Here, we aim to provide a critical 10-year update on the role of ubiquitin-proteasome signaling in synaptic plasticity and memory formation, including updated cellular models of how ubiquitin-proteasome activity could be regulating learning-dependent synaptic plasticity in the brain.

1998年12月15日 · From an unregulated, non‐specific terminal scavenger process, it has become clear that proteolysis of cellular proteins is a highly complex, temporally controlled and tightly regulated process which plays important roles in a broad array of basic cellular processes.