CXCR3 in T cell function - PubMed
2011年3月10日 · CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4(+) T cells and effector CD8(+) T cells. …
CXCR3 in T cell function - PMC - PubMed Central (PMC)
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1 …
The role of CXCR3 and its ligands in cancer - PMC - PubMed …
CXCR3 is present in tumor and immune cells, and its two variants, CXCR3-A and CXCR3-B, have different molecular characteristics and can mediate biological effects with opposite results. Blocking CXCR3-A in tumor cells may be a novel anti-tumor strategy to prevent tumor cell invasion and metastasis.
CXCR3 Gene - GeneCards | CXCR3 Protein | CXCR3 Antibody
2024年12月24日 · CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling .
The duality of CXCR3 in glioblastoma: unveiling autocrine and
2023年12月16日 · This review summarizes existing evidence on the oncogenic function of CXCR3 and its ligands CXCL9, CXCL10, and CXCL11, in GBM, and examines the controversies concerning the immunomodulatory ...
The Role of CXCR3 in Neurological Diseases - PMC - PubMed …
By reviewing the current evidence, we discussed the possible involvement of CXCR3 in neurological diseases. These studies provided hard evidence that CXCR3 plays a vital role in the pathogenesis of MS, glioma, AD, chronic pain, HAM/TSP and bipolar disorder. CXCR3 is a crucial molecule in neuroinflammatory and neurodegenerative diseases.
CXCR3 C-X-C motif chemokine receptor 3 [ (human)] - National …
Human chemokine receptor CXCR3 (CXCR3-B) transduces apoptotic but not chemotactic signals in microvascular endothelial cells following exposure to high concentrations of CXCL4. CXCR3 <-> ligand-mediated lymphocyte recruitment is involved in …
CXCR3 expression in regulatory T cells drives interactions with …
2023年6月30日 · Here, Moreno Ayala et al. show that CXCR3 expression on Treg cells puts them in close proximity to CXCL9-producing dendritic cells in tumors, where they suppress tumor antigen presentation and impede the antitumor CD8+ T cell response.
CXCR3 ligands: redundant, collaborative and antagonistic functions
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation, and preferentially remains highly expressed on type-1 helper (Th1)-type CD4(+) T cells, effector CD8(+) T cells and innate-type lymphocytes, such as natural killer (NK) and NKT cells.
CXCR3 regulates stem and proliferative CD8+ T cells during …
2022年1月18日 · CXCR3 is a chemokine receptor expressed by populations of antigen-experienced CD8+ T cells, including T MEM and T INT cells, and has been implicated in driving T cells into the splenic red pulp and toward an effector fate in settings of early acute infection and vaccination (Hu et al., 2011; Kohlmeier et al., 2011; Kurachi et al., 2011; Shah et ...
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