Functions and inhibitors of CHK1 in cancer therapy
2024年6月1日 · The incorporation of effective biomarkers or combined combinations is expected to promote the development process of CHK1 inhibitors. This paper reviews the latest …
ATR/CHK1 inhibitors and cancer therapy - PubMed Central (PMC)
Here, we review the status of the development of ATR and CHK1 inhibitors. We also discuss the potential mechanisms by which ATR and CHK1 inhibition induces cell killing in the presence or …
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered
2023年4月29日 · SRA737 (Sierra Oncology, Inc., San Mateo, California, USA) is a novel orally bioavailable selective Chk1 inhibitor that has shown single-agent preclinical activity in MYC …
CHK1 inhibition is synthetically lethal with loss of B-family DNA ...
Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell cycle progression, DNA damage repair and DNA replication. Small-molecule CHK1 inhibitors …
Reality CHEK: Understanding the biology and clinical potential of CHK1
2021年1月28日 · CHK1 inhibitor and PARPi combinations are undergoing rapid increases in both preclinical and clinical studies (Table 1). The ATR/CHK1 axis stabilizes replication forks, and …
ATR/CHK1 inhibitors and cancer therapy - PubMed
ATR/CHK1 inhibitors have been developed and are currently used either as single agents or paired with radiotherapy or a variety of genotoxic chemotherapies in preclinical and clinical …
The CHK1 inhibitor prexasertib in - Nature
2024年3月30日 · The multi-cohort phase 2 trial NCT02203513 was designed to evaluate the clinical activity of the CHK1 inhibitor (CHK1i) prexasertib in patients with breast or ovarian cancer.
Roles of Chk1 in Cell Biology and Cancer Therapy - PubMed Central …
Under conventional idea, a Chk1 inhibitor is combined with chemotherapy to enhance the therapy effect. In the novel approach derived from our latest research results, constitutively activating …
Investigational CHK1 inhibitors in early phase clinical trials for the ...
The combination of CHK1 inhibitors with modern signaling regulators may be a better therapeutic strategy. Areas covered: This review discusses the history of, and translational use of CHK1 …
CHK1 inhibitors in combination chemotherapy: thinking beyond the …
2011年11月2日 · This review examines the rationally hypothesized actions of Chk1 inhibitors as cell cycle modulatory drugs as well as the impact of Chk1 inhibition upon other cell survival …