Glucokinase - Wikipedia
Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates.
The Central Role of Glucokinase in Glucose ... - PubMed Central …
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals.
Glucokinase - an overview | ScienceDirect Topics
Glucokinase is the enzyme found in the beta cells of the pancreas that acts as a glucose sensor. Mutations in this enzyme can lead to lower glucose thresholds for insulin secretion, resulting in persistent hypoglycemia with varying clinical severity.
Glucokinase (GCK) in diabetes: from molecular mechanisms to …
2024年9月8日 · Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver.
Glucokinase as an emerging anti-diabetes target and recent …
The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. Diabet Res Clin Pract 2012;98:436–44.
Glucokinase - an overview | ScienceDirect Topics
Glucokinase is a central regulator of glucose homeostasis as evidenced by its association with two disease states, maturity onset diabetes of the young (MODY) and persistent hyperinsulinemia of infancy (PHHI).
Insights into the role of neuronal glucokinase - PMC
Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counterregulatory responses to hypoglycemia and in regulating appetite.
Glucokinase - an overview | ScienceDirect Topics
Glucokinase (GK) is the critical glucose sensor of pancreatic β cells. GK activity is high in the arcuate nucleus; moderate or low in the ventromedial nucleus, lateral hypothalamic area and paraventricular nucleus and very low in the cortex.
The Central Role of Glucokinase in Glucose Homeostasis: A ... - PubMed
2019年3月6日 · It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals.
Glucokinase activity in diabetes: too much of a good thing? - Cell …
2022年12月29日 · Glucokinase is a key beta-cell glucose-sensor that confers the unique ability to respond to plasma glucose levels over a wide range and is essential for insulin secretion. However, this very ability may be detrimental in chronic hyperglycaemia, as the beta-cell has no way to limit glucose metabolism.