Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids.

2021年4月15日 · This review's fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which …

Indole alkaloids, extensively exist in nature, endow with fascinating structural diversity, favorable donor ability, rich photophysical properties, and excellent biocompatibility and occupy a critical position in the discovery of new therapeutics.

Based on their heterocyclic ring system and biosynthetic precursor, alkaloids are classified into diverse categories, viz. indole, purine, quinoline, isoquinoline, tropane, imidazole, among others (Kaur and Arora, 2015; Roy, 2017).

2021年4月15日 · Indole alkaloids have been identified in several prominent plant families, including Apocynaceae, Rubiaceae, Nyssaceae, and Loganiaceae, among others. Some of the identified indole alkaloid compounds have been highly effective in pre-clinical and clinical studies.

Indole alkaloids are a class of compounds with a bicyclic structure, composed of a benzene ring fused to a nitrogen-containing pyrrole ring. They are derived from the amino acid tryptophan and are known for their diverse biological activities, such as anti-hypertensive, anti-cancer, anti-depressant, anti-HIV, and antiproliferative properties.

2020年6月1日 · Indole alkaloids have been increasingly studied, with 261 new compounds being reported from 2012 to 2018, some with promising pharmacological activities. These compounds are found mainly in the families Apocynaceae, Rubiaceae, Annonaceae and Loganiaceae.

…best-known indole-containing compounds are the indole alkaloids, which have been isolated from plants representing more than 30 families. The mushroom hallucinogens psilocin and psilocybin, the ergot fungus alkaloids, the drugs reserpine and yohimbine, and the poison strychnine all belong to this group.

2024年10月9日 · Indole derivatives, such as vinca alkaloids (e.g., vinblastine and vincristine), are key anticancer agents known to inhibit tubulin polymerization . These compounds bind to tubulin and prevent its assembly into microtubules, effectively stopping the cell division process in cancerous cells.

Indole alkaloids are a diverse group of natural compounds that are primarily derived from plants. They are known for their significant pharmacological properties, making them important in...