Tamoxifen - StatPearls - NCBI Bookshelf - National Center for ...
2023年4月10日 · This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, toxicity, and monitoring, of tamoxifen, so providers can direct patient therapy in treating indicated disorders as part of the interprofessional team.
Tamoxifen: Uses, Interactions, Mechanism of Action - DrugBank …
2015年12月30日 · Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
Selective Estrogen Receptor Modulators - PMC
2016年10月4日 · On breast tissue, tamoxifen acts as an estrogen receptor antagonist, but in bone tissue, it acts as an agonist, being able to maintain bone mineral density (BMD) in postmenopausal women.
Tamoxifen - PubMed
2023年4月10日 · This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, toxicity, and monitoring, of tamoxifen, so providers can direct patient therapy in treating indicated disorders as part of the interprofessional team.
Tamoxifen - Wikipedia
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]
Tamoxifen reduces bone resorption and decreases bone turnover as manifested by reductions in bone turnover markers and increases in bone density. Tamoxifen acts mainly on trabecular bone, such as lumbar spine, and has little effect on cortical bone. The effect of tamoxifen on
PharmGKB summary: tamoxifen pathway, pharmacokinetics - PMC
This pathway summary illustrates many of the genes involved in the complex network of tamoxifen metabolism and provides a brief overview of why a variation in these genes may perturb the balance of the different tamoxifen metabolites and …
Tamoxifen: Mechanism of Action - Medscape
2019年12月6日 · Tamoxifen in breast cancer is a drug that acts by binding to and blocking the estrogen receptor. It has an interesting mechanism of action in which it is a partial agonist of the estrogen...
TAMOXIFEN - Pharmaceuticals - NCBI Bookshelf
In women with ductal carcinoma in situ following breast surgery and radiation therapy, tamoxifen is used to reduce the risk of invasive breast cancer. Tamoxifen has been considered as a chemopreventive agent to reduce the incidence of breast cancer in …
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